Finding your new retinal spot after central vision loss

The preferred retinal locus in central vision loss

NIH-funded research University of California Berkeley · NIH-11252338

This project looks at how people with central vision loss from macular disease like AMD use a new part of their retina to do everyday seeing tasks.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionUniversity of California Berkeley NIH-funded
Lab location1 site (Berkeley, United States)
Project IDNIH-11252338 on NIH RePORTER

What this research studies

If you have lost central vision from macular disease, this work will map where on your retina you now look (the preferred retinal locus, or PRL) and test how well that site supports eye movements and visual tasks. The team will use eye-tracking, visual task testing, and retinal imaging to compare the structure and function of different eccentric retinal locations. They will measure where people naturally fixate, how stable that spot is, and whether retinal features predict which location becomes the PRL. The results are intended to guide better vision rehabilitation and training for daily activities.

Who could benefit from this research

Good fit: People with central vision loss from macular disease (such as age-related macular degeneration) who have or are developing an eccentric preferred retinal locus and can attend in-person vision testing are ideal candidates.

Not a fit: People with normal central vision, vision loss not caused by macular disease, or complete blindness are unlikely to benefit directly from this project.

Why it matters

Potential benefit: Could lead to tailored rehabilitation and training that helps people with central vision loss read, recognize faces, and perform daily tasks more effectively.

How similar studies have performed: Previous work has described PRLs and some rehabilitation efforts, but this project combines detailed imaging and behavioral testing to more directly link retinal structure to functional use, which is relatively novel.

Where this research is happening

Berkeley, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions DiseaseDisorder
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.