Finding ways to stop antibiotic resistance in Acinetobacter baumannii
Official title: Inhibitors of adaptive efflux mediated resistance in Acinetobacter baumannii
Funded at University of Rochester · NIH-11039967 · Data updated 2026-11-12
This study is looking at how a tough bacteria called Acinetobacter baumannii becomes resistant to antibiotics and is trying to find new ways to stop it, which could help patients get better treatment for infections that are hard to treat.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | March 7, 2023 |
| Project end | February 29, 2028 |
| Funding year | 2025 |
| Award (this year) | $708,130 |
| NIH project number | 5R01AI175024-03 |
| Project ID | NIH-11039967 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients suffering from infections caused by Acinetobacter baumannii, particularly those who have not responded to standard antibiotic treatments.
✕Less likely to help
Patients with infections caused by other types of bacteria that do not involve Acinetobacter baumannii may not benefit from this research.
What this research studies
This research investigates how Acinetobacter baumannii, a harmful bacteria, develops resistance to antibiotics, particularly through mechanisms known as efflux pumps. The team aims to identify new inhibitors that can block these pumps, potentially restoring the effectiveness of existing antibiotics. By studying how these bacteria adapt to different environments, the researchers hope to discover innovative treatments that can combat infections caused by this resilient pathogen. Patients may benefit from new therapies that could improve outcomes for infections that are currently difficult to treat.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that effectively combat antibiotic-resistant infections caused by Acinetobacter baumannii.
How similar studies have gone: Previous research has shown promise in targeting efflux pumps in other bacteria, suggesting that this approach could be effective for Acinetobacter baumannii as well.
Where this research is happening
-
University of Rochester
Rochester, United States Active
Researchers
- Principal investigator: Dunman, Paul M. — University of Rochester
- Study coordinator: Dunman, Paul M.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.