Finding ways to stabilize important protein interactions in the body
Systematic stabilization of specific protein-protein interactions
This study is looking at ways to strengthen important protein interactions in the body, which could help improve treatments for diseases like cancer and brain disorders, so patients might have better options in the future.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-10915684 on NIH RePORTER |
What this research studies
This research investigates how to stabilize specific protein-protein interactions (PPIs) that are crucial for various biological functions. By focusing on a model protein called 14-3-3, the team aims to develop small-molecule stabilizers that can enhance the function of these proteins. This approach could lead to better understanding and potential treatments for diseases linked to PPI dysregulation, such as cancer and neurodegenerative disorders. Patients may benefit from new therapeutic options that arise from this research.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with conditions linked to dysregulated protein interactions, such as certain cancers or neurodegenerative diseases.
Not a fit: Patients with conditions unrelated to protein-protein interactions may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of new drugs that improve treatment outcomes for patients with diseases related to protein interaction dysregulation.
How similar studies have performed: Other research has shown promise in stabilizing protein interactions, suggesting that this approach could be a valuable avenue for drug discovery.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Arkin, Michelle — University of California, San Francisco
- Study coordinator: Arkin, Michelle
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.