Finding ways to reduce heart rhythm problems caused by certain medications in older adults
Novel Approaches for Minimizing Drug-Induced QT Interval Lengthening
This study is looking at how some common medications can cause heart rhythm problems in older adults and whether hormones like progesterone and testosterone can help protect against these issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Purdue University NIH-funded |
| Lab location | 1 site (West Lafayette, United States) |
| Project ID | NIH-10915699 on NIH RePORTER |
What this research studies
This research investigates how certain medications can lead to dangerous heart rhythm issues, particularly in older adults. It focuses on the QT interval, a measure of heart electrical activity that can be prolonged by over 150 common drugs, increasing the risk of serious conditions like Torsades de Pointes. The study aims to explore the protective effects of hormones like progesterone and testosterone in preventing these drug-induced changes. By evaluating these hormones, the research seeks to identify effective strategies to minimize the risks associated with medication use in older patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults, particularly postmenopausal women and older men, who are at risk of drug-induced QT interval prolongation.
Not a fit: Patients who are younger than 65 or those not taking medications known to prolong the QT interval may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to safer medication practices for older adults, reducing the risk of life-threatening heart conditions.
How similar studies have performed: Previous research has shown promising results in using hormonal therapies to mitigate heart rhythm issues, suggesting potential success for this approach.
Where this research is happening
West Lafayette, United States
- Purdue University — West Lafayette, United States (Active)
Researchers
- Principal investigator: Tisdale, James E. — Purdue University
- Study coordinator: Tisdale, James E.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.