Finding ways to prevent muscle loss in cancer patients
DEVELOPMENT OF TARGETED APPROACHES IN PREVENTION OF CANCER-CACHEXIA
This study is looking at how cancer affects muscle health in patients, especially before they start losing muscle mass, to find new ways to help prevent or reduce that loss by focusing on the role of tiny energy factories in our cells called mitochondria.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Arkansas at Fayetteville NIH-funded |
| Lab location | 1 site (Fayetteville, United States) |
| Project ID | NIH-10877857 on NIH RePORTER |
What this research studies
This research focuses on cancer-cachexia, a condition where cancer patients lose muscle mass that cannot be fully reversed by nutrition alone. The study investigates how mitochondrial health is affected in patients with cancer, particularly looking at the changes that occur before muscle loss happens. By understanding these early changes, the researchers aim to develop targeted therapies that can prevent or reduce muscle loss in cancer patients. The approach includes examining the role of mitochondrial function and antioxidants in muscle health.
Who could benefit from this research
Good fit: Ideal candidates for this research are cancer patients, particularly those at risk of developing cancer-cachexia.
Not a fit: Patients who are not diagnosed with cancer or those who do not exhibit signs of cachexia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to effective treatments that prevent muscle loss in cancer patients, improving their quality of life and potentially extending survival.
How similar studies have performed: While cancer-cachexia is a well-recognized issue, this specific approach targeting mitochondrial health is relatively novel and has not been extensively tested in previous studies.
Where this research is happening
Fayetteville, United States
- University of Arkansas at Fayetteville — Fayetteville, United States (Active)
Researchers
- Principal investigator: Greene, Nicholas Perry — University of Arkansas at Fayetteville
- Study coordinator: Greene, Nicholas Perry
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.