Finding ways to prevent antibiotic resistance in bacteria
Official title: Development of Antibiotic Adjuvants to Avert Resistance Conferred by Cfr, a Radical S-Adenosylmethionine Methylase
Funded at Pennsylvania State University, the · NIH-11001528 · Data updated 2026-11-12
This study is looking for new ways to make antibiotics work better against tough infections caused by resistant bacteria, especially to help vulnerable groups like newborns.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Pennsylvania State University, the NIH-funded |
| Lab location | 1 site (University Park, United States) |
| Project start | December 15, 2023 |
| Project end | October 31, 2025 |
| Funding year | 2025 |
| Award (this year) | $238,275 |
| NIH project number | 5R21AI180902-02 |
| Project ID | NIH-11001528 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals suffering from infections caused by multidrug-resistant bacteria, especially newborns and other high-risk groups.
✕Less likely to help
Patients with infections caused by bacteria that are not resistant to current antibiotics may not receive direct benefits from this research.
What this research studies
This research focuses on developing new antibiotic adjuvants that can help combat the growing problem of antibiotic resistance caused by a specific enzyme called Cfr. By understanding how this enzyme modifies bacterial RNA, the research aims to create strategies that can enhance the effectiveness of existing antibiotics. Patients may benefit from this work as it seeks to improve treatment options for infections caused by multidrug-resistant bacteria, particularly in vulnerable populations like newborns. The approach involves laboratory experiments to test the effectiveness of these adjuvants in overcoming resistance mechanisms.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that restore the effectiveness of antibiotics against resistant bacterial infections.
How similar studies have gone: Other research has shown promise in developing adjuvants to combat antibiotic resistance, indicating that this approach has potential for success.
Where this research is happening
-
Pennsylvania State University, the
University Park, United States Active
Researchers
- Principal investigator: Booker, Squire J. — Pennsylvania State University, the
- Study coordinator: Booker, Squire J.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.