Finding ways to improve treatment for glioblastoma by targeting physical stress mechanisms
Targeting physical stress-driven mechanisms to overcome glioblastoma treatment resistance
['FUNDING_U01'] · MASSACHUSETTS GENERAL HOSPITAL · NIH-10909052
This study is looking at how the pressure and forces from glioblastoma tumors can change how the cancer grows and responds to treatment, with the hope of finding better ways to help patients like you respond to immunotherapy.
Quick facts
| Phase | ['FUNDING_U01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MASSACHUSETTS GENERAL HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10909052 on ClinicalTrials.gov |
What this research studies
This research investigates how mechanical forces generated by glioblastoma tumors affect their growth and resistance to treatment. By studying these forces, the researchers aim to understand how they influence cancer cell behavior and immune responses. The project will use advanced mouse models to test new strategies that could enhance the effectiveness of immunotherapy for glioblastoma patients. The goal is to identify specific pathways that can be targeted to improve treatment outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with glioblastoma multiforme who have limited treatment options.
Not a fit: Patients with other types of brain tumors or those who are not diagnosed with glioblastoma may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for glioblastoma, potentially improving survival rates and quality of life for patients.
How similar studies have performed: While the approach of targeting mechanical stress in tumors is innovative, similar strategies have shown promise in other cancer types, indicating potential for success in glioblastoma.
Where this research is happening
BOSTON, UNITED STATES
- MASSACHUSETTS GENERAL HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MUNN, LANCE L. — MASSACHUSETTS GENERAL HOSPITAL
- Study coordinator: MUNN, LANCE L.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.