Finding ways to improve treatment for glioblastoma by targeting DNA repair mechanisms
Screening for DNA Damage Response Modulators in Glioblastoma Stem Cells
This study is looking at how glioblastoma, a tough type of brain cancer, can sometimes bounce back from treatments like radiation and a common drug called temozolomide, and it aims to find new ways to make these cancer cells easier to treat by blocking their ability to repair themselves.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10683338 on NIH RePORTER |
What this research studies
This research focuses on glioblastoma, a type of brain cancer that currently has no cure and often leads to poor outcomes for patients. The team aims to identify how glioblastoma stem cells repair DNA damage caused by standard treatments like radiation and the drug temozolomide. By developing a sensitive assay, they will screen for compounds that can inhibit these repair processes, potentially making the cancer cells more vulnerable to treatment. This approach could lead to new therapies that enhance the effectiveness of existing treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with glioblastoma who are undergoing standard treatment.
Not a fit: Patients with other types of brain tumors or those who are not currently receiving treatment for glioblastoma may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options for glioblastoma patients, potentially increasing survival rates and quality of life.
How similar studies have performed: Previous research has shown promise in targeting DNA repair mechanisms in cancer, suggesting that this approach could be effective.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Badr, Christian Elias — Massachusetts General Hospital
- Study coordinator: Badr, Christian Elias
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.