Finding ways to improve treatment for colorectal cancer with KRAS mutations
Overcoming adaptive feedback resistance to KRAS inhibition in colorectal cancer
This study is looking at ways to help people with colorectal cancer that has KRAS mutations by finding better treatments that work even when the cancer tries to resist them, and it may involve patients in testing these new approaches.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11059849 on NIH RePORTER |
What this research studies
This research investigates how to overcome resistance to new treatments targeting KRAS mutations in colorectal cancer. It focuses on understanding the mechanisms that lead to treatment failure, particularly the adaptive feedback that allows cancer cells to survive despite therapy. By exploring combination therapies that target these feedback signals, the research aims to enhance the effectiveness of KRAS inhibitors and improve patient outcomes. Patients may be involved in clinical trials that test these new treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are colorectal cancer patients with specific KRAS mutations, particularly those who have not responded well to existing therapies.
Not a fit: Patients with colorectal cancer who do not have KRAS mutations or those who are in advanced stages where treatment options are limited may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for colorectal cancer patients with KRAS mutations, potentially improving survival rates.
How similar studies have performed: Previous research has shown that combination therapies targeting adaptive feedback mechanisms can improve outcomes in other types of colorectal cancer, suggesting a promising approach for this study.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Corcoran, Ryan Bruce — Massachusetts General Hospital
- Study coordinator: Corcoran, Ryan Bruce
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.