Finding ways to improve the immune response against coronavirus infections
Overriding the Immune Evasion Tactics of Coronavirus
This study is looking for new treatments to help people with COVID-19 by finding ways to boost the immune system and stop the virus from spreading in the body.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sanford Burnham Prebys Medical Discovery Institute NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-11146007 on NIH RePORTER |
What this research studies
This research investigates how the coronavirus can evade the immune system and aims to identify new therapeutics that can restore effective immune responses in patients infected with SARS-CoV-2. The approach involves screening various compounds to find those that can block the virus's ability to replicate and disrupt harmful inflammatory responses. By using specialized lung cell lines and human lung organoids, the researchers will test these compounds in controlled laboratory settings to determine their effectiveness. The ultimate goal is to develop new treatments that can help prevent severe COVID-19 outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have tested positive for COVID-19 and are at risk of developing severe symptoms.
Not a fit: Patients who have not been infected with SARS-CoV-2 or those with mild symptoms who do not require therapeutic intervention may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that significantly improve the immune response in COVID-19 patients, potentially reducing the severity of the disease.
How similar studies have performed: Other research has shown promise in developing therapeutics targeting immune responses in viral infections, indicating that this approach could be effective.
Where this research is happening
La Jolla, United States
- Sanford Burnham Prebys Medical Discovery Institute — La Jolla, United States (Active)
Researchers
- Principal investigator: Ware, Carl F — Sanford Burnham Prebys Medical Discovery Institute
- Study coordinator: Ware, Carl F
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.