Finding ways to improve the immune response against Coronavirus
Overriding the Immune Evasion Tactics of Coronavirus
['FUNDING_R01'] · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · NIH-10671613
This study is looking for new medicines that can help your immune system fight off COVID-19 better, especially for those who might get really sick, by testing different compounds in the lab to see which ones can stop the virus and boost your body's defenses.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE (nih funded) |
| Locations | 1 site (LA JOLLA, UNITED STATES) |
| Trial ID | NIH-10671613 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how the Coronavirus can evade the immune system and lead to severe disease. It aims to identify new antiviral drugs that can restore proper immune signaling disrupted by the virus. By using specialized cell lines and lung organoids, the researchers will screen various compounds to find those that can effectively inhibit the virus and enhance the body's defense mechanisms. The ultimate goal is to develop therapeutics that can prevent severe outcomes in COVID-19 patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals infected with SARS-CoV-2 who are at risk of developing severe disease.
Not a fit: Patients who are not infected with SARS-CoV-2 or those with mild symptoms that do not progress to severe disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly reduce the severity of COVID-19 and improve patient outcomes.
How similar studies have performed: Other research has shown promise in developing antiviral therapies targeting immune responses in viral infections, indicating that this approach has potential for success.
Where this research is happening
LA JOLLA, UNITED STATES
- SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE — LA JOLLA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WARE, CARL F — SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE
- Study coordinator: WARE, CARL F
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.