Finding ways to improve stem cell function in older adults
Discovery and manipulation of transcription factors to restore long term stem cell repopulation in aged bone-marrow
['FUNDING_R01'] · BRIGHAM AND WOMEN'S HOSPITAL · NIH-11116865
This study is looking at how getting older affects the bone marrow's stem cells, which are important for keeping our immune system strong, and it aims to find ways to boost these cells in older people to help improve their health.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BRIGHAM AND WOMEN'S HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-11116865 on ClinicalTrials.gov |
What this research studies
This research investigates how aging affects the ability of hematopoietic stem cells in the bone marrow to regenerate and differentiate, which is crucial for maintaining a healthy immune system. The team aims to identify specific transcription factors that can be manipulated to enhance the self-renewal capacity of these stem cells in older individuals. By profiling stem cells and understanding the changes that occur with age, the researchers hope to develop new therapies that could rejuvenate the bone marrow and improve overall health. The approach includes exploring innovative methods like partial reprogramming to stimulate stem cell activity.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults experiencing age-related decline in immune function or other health issues linked to aging.
Not a fit: Patients who are younger or do not have age-related health conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to therapies that restore immune function and improve health outcomes for older adults.
How similar studies have performed: Previous research has shown promise in using transcription factors to rejuvenate stem cells, indicating potential for success in this novel approach.
Where this research is happening
BOSTON, UNITED STATES
- BRIGHAM AND WOMEN'S HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ABUDAYYEH, OMAR O — BRIGHAM AND WOMEN'S HOSPITAL
- Study coordinator: ABUDAYYEH, OMAR O
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: age associated disease, age associated disorder