Finding ways to improve mitochondrial function in aging-related diseases
Official title: Identification of genetic and environmental suppressors of mitochondrial dysfunction
Funded at Brandeis University · NIH-11231304 · Data updated 2026-11-12
This study is looking at how genes and the environment can help boost the energy-making parts of our cells, which is especially important for people with conditions like Alzheimer's and Parkinson's, and it might lead to new ways to improve health as we age.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brandeis University NIH-funded |
| Lab location | 1 site (Waltham, United States) |
| Project start | January 1, 2021 |
| Project end | December 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $249,000 |
| NIH project number | 4R00GM140217-03 |
| Project ID | NIH-11231304 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals experiencing age-related diseases, particularly those with Alzheimer's or Parkinson's disease.
✕Less likely to help
Patients with mitochondrial diseases caused by specific genetic mutations that are not addressed by this research may not benefit.
What this research studies
This research investigates how genetic and environmental factors can help improve mitochondrial function, which is crucial for energy production in cells. By using a model organism called C. elegans, the researchers aim to identify new genetic suppressors that can counteract mitochondrial dysfunction, particularly in diseases like Alzheimer's and Parkinson's. The study will explore the effects of hypoxia, or low oxygen levels, on mitochondrial health and its potential as a treatment strategy. Patients may benefit from insights gained about how to enhance mitochondrial function and potentially slow the progression of age-related diseases.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating age-related diseases by improving mitochondrial function.
How similar studies have gone: Previous research has shown promise in using genetic and environmental approaches to address mitochondrial dysfunction, suggesting potential for success in this area.
Where this research is happening
-
Brandeis University
Waltham, United States Active
Researchers
- Principal investigator: Meisel, Joshua Daniel — Brandeis University
- Study coordinator: Meisel, Joshua Daniel
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.