Finding ways to improve metabolic health in people living with HIV
Official title: An Innovative Approach to Identify Correctors of Metabolic Complications in HIV
Funded at Scripps Research Institute, the · NIH-11011324 · Data updated 2026-11-12
This study is looking for new treatments to help people with HIV who are dealing with weight gain and cholesterol problems caused by their medications, by testing a variety of potential drugs to find ones that can improve their health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Scripps Research Institute, the NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | January 15, 2024 |
| Project end | November 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $925,072 |
| NIH project number | 5R01DK137675-02 |
| Project ID | NIH-11011324 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals living with HIV who are experiencing metabolic complications related to their condition or treatment.
✕Less likely to help
Patients who are not living with HIV or those who do not have metabolic complications may not benefit from this research.
What this research studies
This research focuses on addressing the metabolic complications that arise in individuals living with HIV, particularly those related to antiretroviral therapy. The team will utilize a high-throughput screening method to identify specific chemical compounds that can correct these metabolic issues. By analyzing a large library of potential drug candidates, they aim to find effective treatments that can help manage conditions like obesity and dyslipidemia, which are common in this population. The research involves collaboration between two prominent biomedical institutions to ensure a comprehensive approach to drug discovery.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly improve metabolic health and reduce the risk of cardiovascular disease in people living with HIV.
How similar studies have gone: Previous research has shown promise in identifying metabolic interventions for HIV patients, but this specific approach using high-throughput screening is relatively novel.
Where this research is happening
-
Scripps Research Institute, the
La Jolla, United States Active
Researchers
- Principal investigator: Sanna, Pietro P — Scripps Research Institute, the
- Study coordinator: Sanna, Pietro P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.