Finding ways to improve blood health as people age
Developing Effective Approaches to Extend Hematopoietic Healthspan by Targeting Cell-Extrinsic and Cell-Intrinsic Alterations at Middle Age
This study is looking at how getting older affects our blood system, especially a condition called clonal hematopoiesis that can lead to serious health problems like blood cancer and diabetes, and it aims to find ways to improve blood health and help people live healthier lives as they age.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Jackson Laboratory NIH-funded |
| Lab location | 1 site (Bar Harbor, United States) |
| Project ID | NIH-11042801 on NIH RePORTER |
What this research studies
This research investigates how aging affects the blood system, particularly focusing on a condition called clonal hematopoiesis (CH), which can lead to serious health issues like blood cancer and diabetes. The study aims to understand the mechanisms behind CH and how both internal and external factors contribute to its development as people age. By using mouse models, researchers will explore how certain mutations in blood stem cells interact with the aging environment to promote health decline. The ultimate goal is to identify effective strategies to enhance blood health and extend the healthy lifespan of individuals.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults who may be experiencing age-related health issues, particularly those at risk for blood cancers or diabetes.
Not a fit: Patients who are younger and do not have any age-related health concerns may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new interventions that improve blood health and reduce the risk of diseases associated with aging.
How similar studies have performed: Other research has shown promising results in understanding age-related changes in blood health, making this approach both relevant and potentially impactful.
Where this research is happening
Bar Harbor, United States
- Jackson Laboratory — Bar Harbor, United States (Active)
Researchers
- Principal investigator: Trowbridge, Jennifer Jean — Jackson Laboratory
- Study coordinator: Trowbridge, Jennifer Jean
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.