Finding ways to eliminate HIV reservoirs in the brain
Metabolic strategies to eliminate CNS Myeloid Viral Reservoirs
['FUNDING_R01'] · UNIVERSITY OF TEXAS MED BR GALVESTON · NIH-11083001
This study is looking at how HIV hides in certain brain cells and is trying to find new ways to get rid of the virus from these cells, which is important for people living with HIV who want to stay healthy.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF TEXAS MED BR GALVESTON (nih funded) |
| Locations | 1 site (GALVESTON, UNITED STATES) |
| Trial ID | NIH-11083001 on ClinicalTrials.gov |
What this research studies
This research investigates how HIV persists in myeloid cells, particularly in the brain, and explores metabolic strategies to eliminate these viral reservoirs. The study focuses on understanding the role of macrophages and microglia in harboring latent HIV, which can reactivate upon interruption of antiretroviral therapy. By developing an in vitro system to study these cells, the research aims to identify effective treatments that can target and eliminate the virus from these long-lasting reservoirs.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who have been on antiretroviral therapy and may have latent viral reservoirs in their brain.
Not a fit: Patients who are not living with HIV or those who have not been on antiretroviral therapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that effectively eliminate HIV from the brain, potentially curing patients with HIV.
How similar studies have performed: While research on HIV reservoirs has been ongoing, this specific approach targeting myeloid cells in the brain is relatively novel and has not been extensively tested.
Where this research is happening
GALVESTON, UNITED STATES
- UNIVERSITY OF TEXAS MED BR GALVESTON — GALVESTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: EUGENIN, ELISEO A — UNIVERSITY OF TEXAS MED BR GALVESTON
- Study coordinator: EUGENIN, ELISEO A
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome Virus, Acquired Immunodeficiency Syndrome Virus