Finding ways to eliminate HIV from the body.
Official title: Antagonize Host Survival and Immune Escape Mechanisms for Elimination of HIV Viral Reservoirs
Funded at Ohio State University · NIH-11035853 · Data updated 2026-11-12
This study is looking at how HIV stays in the body even when people are on treatment, and it aims to find new ways to get rid of the virus for good by understanding how HIV interacts with the immune system, especially focusing on a protein called Nef that helps infected cells survive.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project start | March 14, 2024 |
| Project end | February 28, 2026 |
| Funding year | 2024 |
| Award (this year) | $841,702 |
| NIH project number | 1R56AI181631-01A1 |
| Project ID | NIH-11035853 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals living with HIV who are currently on antiretroviral therapy but still have detectable viral reservoirs.
✕Less likely to help
Patients who are not infected with HIV or those who have advanced AIDS with significant comorbidities may not benefit from this research.
What this research studies
This research investigates how HIV persists in the body despite treatment and aims to identify new strategies to eliminate the virus. It focuses on understanding the interactions between HIV and the host's immune system, particularly the role of a viral protein called Nef in promoting the survival of infected cells. By targeting specific cellular mechanisms, the research seeks to enhance the death of HIV-infected cells and reduce viral reservoirs, potentially leading to a cure for HIV/AIDS.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that effectively eliminate HIV from the body, offering hope for a cure.
How similar studies have gone: Previous research has shown promise in targeting viral proteins to enhance the elimination of HIV, indicating that this approach could be effective.
Where this research is happening
-
Ohio State University
Columbus, United States Active
Researchers
- Principal investigator: Zhu, Jian — Ohio State University
- Study coordinator: Zhu, Jian
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.