Finding ways to detect aging cells in the body
Evaluating diverse technologies for detecting and validating senescent cells in vivo
This study is looking at special cells that stop dividing as we age and can cause health problems, and it aims to find better ways to spot these cells in both lab models and people, with the hope of improving treatments for age-related issues.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Buck Institute for Research on Aging NIH-funded |
| Lab location | 1 site (Novato, United States) |
| Project ID | NIH-10915692 on NIH RePORTER |
What this research studies
This research investigates how to identify and validate senescent cells, which are cells that have stopped dividing and can contribute to age-related diseases. The study uses advanced single-cell profiling techniques to analyze these cells in both model systems and human subjects. By understanding the characteristics of senescent cells and their impact on health, the research aims to improve detection methods that could lead to better treatments for age-related conditions. Patients may be involved in the human validation phase to help confirm the findings.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults experiencing age-related health issues or those interested in the biological processes of aging.
Not a fit: Patients who are younger and do not have any age-related conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved detection and treatment strategies for age-related diseases, enhancing overall health in older adults.
How similar studies have performed: Other research has shown promising results in identifying senescent cells using various profiling techniques, indicating that this approach has potential for success.
Where this research is happening
Novato, United States
- Buck Institute for Research on Aging — Novato, United States (Active)
Researchers
- Principal investigator: Melov, Simon — Buck Institute for Research on Aging
- Study coordinator: Melov, Simon
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.