Finding ways to boost energy levels in vulnerable human cells
Defining Strategies to Target Energy Failure in Metabolically Vulnerable Human Cells
['FUNDING_R01'] · J. DAVID GLADSTONE INSTITUTES · NIH-10844591
This study is looking for ways to help human cells that are struggling to produce energy, which is important for their survival, especially in people with conditions like cancer and neurodegenerative diseases, by finding out which genes and pathways can boost their energy levels.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | J. DAVID GLADSTONE INSTITUTES (nih funded) |
| Locations | 1 site (SAN FRANCISCO, UNITED STATES) |
| Trial ID | NIH-10844591 on ClinicalTrials.gov |
What this research studies
This research investigates how to enhance energy production in human cells that are at risk of dysfunction and death due to energy failure. By using advanced techniques like high throughput screening with fluorescent biosensors, the team aims to identify genes and pathways that can increase ATP levels, which are crucial for cell survival and function. The study will explore various mechanisms to boost energy levels and assess their effectiveness in improving the health of cells affected by conditions such as cancer and neurodegenerative diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from conditions associated with energy failure, such as certain cancers, neurodegenerative diseases, or age-related disorders.
Not a fit: Patients with conditions unrelated to energy metabolism or those who are not experiencing cellular dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve cellular function and survival in patients with energy-related diseases.
How similar studies have performed: Other research has shown promise in targeting energy metabolism for therapeutic benefits, suggesting that this approach could be effective.
Where this research is happening
SAN FRANCISCO, UNITED STATES
- J. DAVID GLADSTONE INSTITUTES — SAN FRANCISCO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: NAKAMURA, KEN — J. DAVID GLADSTONE INSTITUTES
- Study coordinator: NAKAMURA, KEN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers, neoplasm/cancer