Finding the RNA pieces and proteins that control how circular RNAs make proteins
Systematic identification of RNA sequences and protein components regulating circular RNA translation
['FUNDING_OTHER'] · WASHINGTON UNIVERSITY · NIH-11196211
This project searches for the RNA sequences and proteins that control circular RNAs making proteins, with the goal of improving our understanding of cancer biology for patients down the line.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WASHINGTON UNIVERSITY (nih funded) |
| Locations | 1 site (SAINT LOUIS, UNITED STATES) |
| Trial ID | NIH-11196211 on ClinicalTrials.gov |
What this research studies
Researchers will use a new high-throughput reporter assay to screen thousands of RNA sequences and identify which ones start protein production from circular RNAs versus linear RNAs. They will combine these screens with molecular tools, including CRISPR-based methods, to turn genes or protein factors on and off in lab-grown cells and see how that changes circular RNA translation. The team will compare results to find protein partners and sequence motifs that specifically regulate circular RNA translation. All work is laboratory-based using cell models and molecular assays rather than enrolling patients.
Who could benefit from this research
Good fit: While this grant does not recruit patients, future related studies would most likely involve people with cancers suspected to involve abnormal circular RNA activity.
Not a fit: Patients seeking immediate treatment should not expect direct benefit from this lab-focused project, since it does not provide clinical care or therapies.
Why it matters
Potential benefit: If successful, this work could reveal new biomarkers or drug targets that someday help prevent or treat cancers driven by abnormal circular RNA translation.
How similar studies have performed: Basic research has shown that circular RNAs can be translated and influence cancer, but this specific high-throughput screening approach is novel and not yet tested in clinical settings.
Where this research is happening
SAINT LOUIS, UNITED STATES
- WASHINGTON UNIVERSITY — SAINT LOUIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CHEN, CHUN-KAN — WASHINGTON UNIVERSITY
- Study coordinator: CHEN, CHUN-KAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.