Finding the right balance of immune response in Alzheimer's disease
Official title: Searching for the Goldilocks Zone of Innate Immunity in Alzheimer's Disease
Funded at Emory University · NIH-10985277 · Data updated 2026-11-12
This study is looking at how the immune system works with Alzheimer's disease to find safe treatments that could help improve the condition without causing side effects.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project start | September 26, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $1,010,081 |
| NIH project number | 1R01AG085557-01A1 |
| Project ID | NIH-10985277 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals at risk for or diagnosed with Alzheimer's disease who may benefit from innovative immune therapies.
✕Less likely to help
Patients with advanced Alzheimer's disease or those who do not have amyloid pathology may not receive benefit from this research.
What this research studies
This research investigates how the immune system interacts with Alzheimer's disease and aims to identify immune therapies that can help modify the disease without causing harm. By studying preclinical models, the researchers will explore various immune manipulations to find a 'Goldilocks zone'—a state where the immune response is just right for benefiting patients. The study will evaluate both the potential benefits and risks of these immune therapies, focusing on their effects on amyloid pathology in the brain. Through systematic testing, the goal is to develop safe and effective treatments for Alzheimer's disease.
Why it matters
Potential benefit: If successful, this research could lead to new immune-based therapies that effectively modify the progression of Alzheimer's disease with minimal side effects.
How similar studies have gone: Previous research has shown promise in using immune therapies for neurodegenerative diseases, but this specific approach to finding a 'Goldilocks zone' in Alzheimer's is novel.
Where this research is happening
-
Emory University
Atlanta, United States Active
Researchers
- Principal investigator: Golde, Todd E — Emory University
- Study coordinator: Golde, Todd E
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.