Finding the genes that shape complex traits and disease risk
Deconstructing the Genetic Basis of Complex Trait Variation
['FUNDING_OTHER'] · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · NIH-11325704
Researchers will use large genetic and health datasets to find which genes influence complex traits and diseases, with a focus on blood cell measures.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NEW YORK UNIVERSITY SCHOOL OF MEDICINE (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11325704 on ClinicalTrials.gov |
What this research studies
Using health and genetic data from thousands of people like you, researchers will trace how DNA differences change traits and disease risk. They will create new statistical tools that combine molecular biology and population genetics ideas about natural selection. The team will compare signals from common non-coding variants (found by GWAS) with rare damaging mutations in genes to see which genes matter most. They will test these approaches on blood cell measurements using the UK Biobank and All of Us datasets.
Who could benefit from this research
Good fit: Ideal participants are people already enrolled in large genetic biobanks or who have genetic data linked to health records, especially those with blood cell measurements.
Not a fit: People without genetic or linked health-data records or those whose conditions are driven mainly by non-genetic factors may not see direct benefits.
Why it matters
Potential benefit: Could help pinpoint specific genes behind complex diseases and guide development of better tests or treatments.
How similar studies have performed: GWAS have successfully found many disease-linked variants, but combining population genetics and molecular data to pinpoint causal genes is a relatively new and developing approach.
Where this research is happening
NEW YORK, UNITED STATES
- NEW YORK UNIVERSITY SCHOOL OF MEDICINE — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MOSTAFAVI, HAKHAMANESH — NEW YORK UNIVERSITY SCHOOL OF MEDICINE
- Study coordinator: MOSTAFAVI, HAKHAMANESH
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Disease