Finding the best ways to take short breaks from sitting to improve heart health

Breaking up Prolonged Sedentary Behavior to Improve Cardiometabolic Health: An Adaptive Dose-Finding Study

NIH-funded research Columbia University Health Sciences · NIH-11072049

This research aims to discover the most effective and comfortable ways for adults to take short breaks from sitting to help prevent heart disease.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionColumbia University Health Sciences NIH-funded
Lab location1 site (New York, United States)
Project IDNIH-11072049 on NIH RePORTER

What this research studies

Many of us sit for long periods, which can be harmful to our heart health. While we know that moving more and sitting less is good, we don't have clear guidelines on how often or for how long these "sedentary breaks" should be. This project will carefully test different frequencies and durations of short activity breaks to find out what works best. Our goal is to provide clear, practical advice that people can easily follow to improve their heart and metabolic health.

Who could benefit from this research

Good fit: This opportunity is designed for adults aged 21 and older who are interested in improving their heart and metabolic health through behavioral changes.

Not a fit: Patients who are unable to incorporate regular physical activity breaks into their daily routine may not directly benefit from this specific intervention.

Why it matters

Potential benefit: If successful, this research will provide clear, actionable guidelines for how often and for how long people should take breaks from sitting to reduce their risk of heart disease.

How similar studies have performed: While general recommendations exist to sit less, this specific approach to rigorously determine the optimal frequency and duration of sedentary breaks is novel and has not been thoroughly tested.

Where this research is happening

New York, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions Cardiovascular Diseases
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.