Finding the best ways to help people quit smoking using medications and virtual support.

Comparative Effectiveness of Sequential Pharmacotherapeutic Strategies and Virtually Delivered Treatment to Optimize Smoking Cessation

NIH-funded research University of Tx Md Anderson Can Ctr · NIH-11002710

This study is looking for ways to help adults quit smoking by testing different medications and virtual counseling options, so if you're trying to quit, you might get personalized support to find what works best for you!

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionUniversity of Tx Md Anderson Can Ctr NIH-funded
Lab location1 site (Houston, United States)
Project IDNIH-11002710 on NIH RePORTER

What this research studies

This research aims to improve smoking cessation methods by comparing different medication strategies and virtual counseling for smokers. It will involve a large group of adult participants who are trying to quit smoking, using a Sequential Multiple Assignment Randomized Trial (SMART) design to tailor treatments based on individual responses. Participants will receive either varenicline or nicotine replacement therapy, and those who do not succeed will have options to continue, switch, or enhance their treatment. The goal is to provide effective, accessible support for smokers through virtual delivery, making it easier for them to quit.

Who could benefit from this research

Good fit: Ideal candidates for this research are adults over 21 years old who are motivated to quit smoking.

Not a fit: Patients who are not seeking to quit smoking or are under 21 years old may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could lead to more effective and personalized smoking cessation treatments that are easily accessible to patients.

How similar studies have performed: Previous research has shown promising results with similar pharmacotherapy and counseling approaches for smoking cessation, indicating potential for success in this study.

Where this research is happening

Houston, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.