Finding the best way to use tranexamic acid to prevent postpartum bleeding
Official title: OPTIMUM OB-TXA: Optimal TIMing, route and dose of tranexamic acid prior to UMbilical cord clamp for postpartum hemorrhage prevention
Funded at Inova Health Care Services · NIH-10903995 · Data updated 2026-11-12
This study is looking at the best ways to use a medication called tranexamic acid to help prevent heavy bleeding after childbirth, and it's for women who are having a baby vaginally, through a cesarean section, or who have obesity, so we can find the safest and most effective options for both moms and their babies.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Inova Health Care Services NIH-funded |
| Lab location | 1 site (Fairfax, UNITED STATES) |
| Project start | August 9, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $556,408 |
| NIH project number | 5R01HD110109-03 |
| Project ID | NIH-10903995 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include pregnant women who are planning to deliver vaginally or via cesarean section, particularly those with morbid obesity.
✕Less likely to help
Patients who are not pregnant or those who do not plan to deliver in the study's timeframe may not benefit from this research.
What this research studies
This research investigates how to effectively use tranexamic acid (TXA) to prevent postpartum hemorrhage (PPH) by examining different timing, routes, and doses of administration before umbilical cord clamping during childbirth. The study will focus on three specific groups: women delivering vaginally, those undergoing cesarean sections, and those with morbid obesity. Researchers will measure TXA levels in umbilical cord blood and breast milk, as well as monitor clinical outcomes for mothers and newborns at delivery and two to six weeks postpartum. The goal is to maximize benefits for mothers while minimizing risks for both mothers and their babies.
Why it matters
Potential benefit: If successful, this research could significantly reduce the incidence of postpartum hemorrhage, improving maternal health outcomes.
How similar studies have gone: Previous research has shown that tranexamic acid can be effective in reducing bleeding in various surgical settings, suggesting potential success in this novel application for postpartum hemorrhage.
Where this research is happening
-
Inova Health Care Services
Fairfax, United States Active
Researchers
- Principal investigator: Ahmadzia, Homa Khorrami — Inova Health Care Services
- Study coordinator: Ahmadzia, Homa Khorrami
Related research
Other NIH-funded projects on the same topics.
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Wearable tech to track blood loss during childbirth
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Maternal Postpartum Monitoring with a Wearable Sensor (MOMS)
A wearable system called MOMS will continuously monitor multiple physiological signals in pregnant people to detect postpartum hemorrhage earlier than standard vital signs.
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AI-powered real-time postpartum hemorrhage risk predictor in clinical care
A real-time AI tool integrated into electronic health records helps identify women at risk for postpartum hemorrhage so clinicians can intervene earlier.
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Targeting Ubiquitination to Improve Uterotonic Therapies in Postpartum Hemorrhage
A new approach aims to boost uterine contractions during childbirth and after delivery by understanding how a hormone receptor is regulated, potentially reducing postpartum hemorrhage risk.
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Personalized Postpartum Bleeding Risk Prediction with Machine Learning and Genetic Scores
This grant aims to create a personalized tool that predicts a mother’s risk of postpartum hemorrhage using machine learning and her genetic information.
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OPTIMUM OB-TXA: Timing, route, and dose of tranexamic acid to prevent postpartum bleeding before cord clamping
Aims to find the best time, method, and amount of tranexamic acid given before cord clamping to prevent postpartum hemorrhage in new mothers and protect babies.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.