Finding the best radiation treatment for glioblastoma using human brain models
Determining the optimal ion and fractionation scheme for the treatment of GBM in a comprehensive human organoid model
This study is looking at how to make radiation treatments better for people with glioblastoma, a tough type of brain cancer, by using special models that mimic the human brain to see how different radiation doses can target the tumor while protecting healthy brain cells.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tx Md Anderson Can Ctr NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-11031391 on NIH RePORTER |
What this research studies
This research investigates how different radiation treatments can be optimized for glioblastoma, a highly aggressive brain cancer. By using advanced human brain organoid models, the study aims to understand how various radiation doses affect tumor cells and surrounding healthy brain tissue. The approach includes testing high-energy particle beams to improve tumor control while minimizing damage to normal brain cells. This research could lead to more effective and safer treatment options for patients with glioblastoma.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with glioblastoma who are seeking innovative treatment options.
Not a fit: Patients with other types of brain tumors or those who are not eligible for radiation therapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide patients with glioblastoma more effective radiation therapies that improve survival rates and reduce side effects.
How similar studies have performed: Previous research has shown promise in using advanced models to improve cancer treatment outcomes, suggesting that this approach could yield significant advancements.
Where this research is happening
Houston, United States
- University of Tx Md Anderson Can Ctr — Houston, United States (Active)
Researchers
- Principal investigator: Grosshans, David R — University of Tx Md Anderson Can Ctr
- Study coordinator: Grosshans, David R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.