Finding the best oxygen levels for newborns with lung injury
Official title: Optimal Oxygenation in Neonatal Lung Injury
Funded at University of California at Davis · NIH-11089518 · Data updated 2026-11-12
This study is looking at how different levels of oxygen can help newborns with lung injuries, especially those with conditions like HIE and PPHN, by comparing higher oxygen levels to the usual ones during cooling treatment, and it will also test a medication to improve blood flow and protect their brains.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project start | August 1, 2023 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $683,086 |
| NIH project number | 5R01HD072929-14 |
| Project ID | NIH-11089518 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are newborns diagnosed with hypoxic-ischemic encephalopathy or persistent pulmonary hypertension.
✕Less likely to help
Patients who are not newborns or those without lung injuries related to birth asphyxia may not benefit from this research.
What this research studies
This research investigates how different oxygen levels affect newborns suffering from lung injuries, particularly those with conditions like hypoxic-ischemic encephalopathy (HIE) and persistent pulmonary hypertension of the newborn (PPHN). The study will compare the effects of targeting higher oxygen saturation levels (95-98%) versus the current standard (91-95%) during therapeutic hypothermia. It will also explore the use of intravenous sildenafil to improve blood flow and reduce brain injury. By monitoring changes in gas exchange and brain blood flow, the research aims to identify the best treatment strategies for these vulnerable infants.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment protocols that enhance recovery and outcomes for newborns with lung injuries.
How similar studies have gone: Previous research has shown promising results with similar approaches in optimizing oxygenation for newborns, indicating potential for success in this study.
Where this research is happening
-
University of California at Davis
Davis, United States Active
Researchers
- Principal investigator: Lakshminrusimha, Satyanarayana — University of California at Davis
- Study coordinator: Lakshminrusimha, Satyanarayana
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.