Finding the best drug dosages to improve patient care
Official title: Democratically Designed Optimal Dosing Regimens To Combat Overuse
Funded at Veterans Health Administration · NIH-10992724 · Data updated 2026-11-12
This study is all about finding the right amount of new medicines for Veterans, so they can get the benefits without dealing with too many side effects, and it involves Veterans in figuring out the best ways to test these lower doses safely.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Veterans Health Administration NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | January 1, 2025 |
| Project end | December 31, 2029 |
| Funding year | 2025 |
| NIH project number | 1IK2HX003682-01A2 |
| Project ID | NIH-10992724 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are Veterans who are prescribed newly-approved precision medicines and may benefit from optimized dosing regimens.
✕Less likely to help
Patients who are not Veterans or those not receiving precision medicines may not benefit from this research.
What this research studies
This research focuses on optimizing drug dosages for newly-approved precision medicines, particularly for Veterans. It aims to address the issue of excessively high dosages that can lead to unnecessary side effects and reduced access to care. By engaging Veterans in the research design, the project seeks to develop new trial methodologies that test lower dosages while ensuring safety and efficacy. The approach includes using response-adaptive randomized trials, which adjust treatment assignments based on interim results, making the process more responsive to patient needs.
Why it matters
Potential benefit: If successful, this research could lead to safer and more effective drug dosing for Veterans, enhancing their access to necessary treatments.
How similar studies have gone: While the approach of optimizing drug dosages is gaining attention, this specific methodology of engaging Veterans in the design of dosing trials is relatively novel.
Where this research is happening
-
Veterans Health Administration
Ann Arbor, United States Active
Researchers
- Principal investigator: Strohbehn, Garth — Veterans Health Administration
- Study coordinator: Strohbehn, Garth
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.