Finding the best buprenorphine dose for treating opioid addiction and preventing overdose
Identifying optimal buprenorphine dosing for OUD treatment and prevention of overdose
['FUNDING_OTHER'] · BROWN UNIVERSITY · NIH-11126296
This study is looking at whether higher doses of buprenorphine can help people with opioid use disorder, especially those who have used fentanyl, feel better and manage their cravings more effectively than the usual doses.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BROWN UNIVERSITY (nih funded) |
| Locations | 1 site (PROVIDENCE, UNITED STATES) |
| Trial ID | NIH-11126296 on ClinicalTrials.gov |
What this research studies
This research investigates how different doses of buprenorphine can effectively treat opioid use disorder (OUD), particularly in patients who have used fentanyl. The study aims to determine if higher doses of buprenorphine can better manage withdrawal symptoms and cravings compared to standard doses. By conducting a randomized controlled trial, the research will compare treatment outcomes for patients using fentanyl with those receiving traditional dosing protocols. The goal is to establish updated guidelines for buprenorphine dosing that can improve patient outcomes and reduce overdose risks.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with opioid use disorder, particularly those with a history of fentanyl use.
Not a fit: Patients who are not struggling with opioid use disorder or who have not used fentanyl may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatment protocols for opioid addiction, significantly reducing the risk of overdose and improving recovery rates.
How similar studies have performed: While there is existing evidence suggesting higher doses of buprenorphine may be beneficial, this specific approach has not been extensively tested in a randomized controlled trial setting.
Where this research is happening
PROVIDENCE, UNITED STATES
- BROWN UNIVERSITY — PROVIDENCE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BEAUDOIN, FRANCESCA — BROWN UNIVERSITY
- Study coordinator: BEAUDOIN, FRANCESCA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: addictive disorder