Finding the best anti-arrhythmic drugs for heart rhythm patients
Personalizing Class I anti-Arrhythmic Drug Therapy
This study is looking to help people with irregular heartbeats by figuring out which heart medications work best for them based on their genes and heart data from devices they wear, so they can get better treatment with fewer side effects.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-10811741 on NIH RePORTER |
What this research studies
This research aims to enhance treatment outcomes for patients with ventricular arrhythmias by predicting the most effective anti-arrhythmic drug regimen tailored to individual patients. By utilizing genomic data and heart rhythm reports from wearable and implanted devices, the study seeks to identify how genetic variations and heart responses influence the effectiveness of drugs like mexiletine, which has fewer side effects compared to commonly used amiodarone. The project will involve creating predictive models based on these insights and testing them in a clinical setting to improve patient care.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients suffering from ventricular arrhythmias who may benefit from personalized anti-arrhythmic drug therapy.
Not a fit: Patients who do not have ventricular arrhythmias or those who are not candidates for anti-arrhythmic drug therapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more personalized and effective anti-arrhythmic therapies, reducing side effects and improving quality of life for patients.
How similar studies have performed: Other research has shown promise in using genetic data to tailor drug therapies, suggesting that this approach could be effective.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Silva, Jonathan R — Washington University
- Study coordinator: Silva, Jonathan R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.