Finding TB that comes back after treatment
TB Aftermath
['FUNDING_R01'] · JOHNS HOPKINS UNIVERSITY · NIH-11123105
This project compares two ways to find people in India who develop tuberculosis again after finishing TB treatment to see which finds more cases and gets them back into care.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | JOHNS HOPKINS UNIVERSITY (nih funded) |
| Locations | 1 site (BALTIMORE, UNITED STATES) |
| Trial ID | NIH-11123105 on ClinicalTrials.gov |
What this research studies
If you finished TB treatment, this work compares two outreach approaches to find people who develop TB again. People who completed treatment in selected Indian clinics will be followed and randomly assigned to different active case-finding methods like community screening or phone/clinic follow-up, with diagnostic testing when indicated. The team will measure how many recurrent cases are found, how quickly they are diagnosed, the costs, and how practical each approach is to run. The goal is to choose an approach the national TB program can scale up to reduce missed recurrent cases.
Who could benefit from this research
Good fit: People in India who recently completed treatment for tuberculosis, especially those with risk factors like diabetes or heavy alcohol use, are the ideal candidates.
Not a fit: People without a prior TB episode, those who finished treatment long ago, or those living outside the trial communities are unlikely to benefit directly from this project.
Why it matters
Potential benefit: Could help identify recurrent TB sooner so people get treatment earlier and reduce onward transmission.
How similar studies have performed: Active case-finding has identified undiagnosed TB in other programs, but randomized evidence specifically comparing strategies for detecting recurrent TB is limited and more data are needed.
Where this research is happening
BALTIMORE, UNITED STATES
- JOHNS HOPKINS UNIVERSITY — BALTIMORE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GOLUB, JONATHAN E. — JOHNS HOPKINS UNIVERSITY
- Study coordinator: GOLUB, JONATHAN E.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Diabetes Mellitus