Finding specific targets related to Kawasaki Disease
Official title: Identifying Specific Antigenic Targets of Kawasaki Disease
Funded at Lurie Children's Hospital of Chicago · NIH-10894818 · Data updated 2026-11-12
This study is looking at Kawasaki Disease in kids to find out what triggers the immune response, which could help doctors diagnose it earlier and prevent serious heart problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Lurie Children's Hospital of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | September 22, 2020 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $414,612 |
| NIH project number | 5R01AI150719-05 |
| Project ID | NIH-10894818 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children under 11 years old who have been diagnosed with Kawasaki Disease.
✕Less likely to help
Patients who are older than 11 years or do not have Kawasaki Disease may not benefit from this research.
What this research studies
This research investigates Kawasaki Disease (KD), a serious condition that can lead to heart disease in children. The team is working to identify the specific antigens associated with KD by analyzing the immune response in affected children. They are using advanced techniques such as single cell RT-PCR and monoclonal antibody production to pinpoint these antigens, which could lead to better diagnostic tests and treatments. The goal is to improve early diagnosis and reduce the risk of severe complications like coronary artery aneurysms.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic tests and therapies for Kawasaki Disease, ultimately reducing the risk of heart complications in children.
How similar studies have gone: Previous research has shown promise in identifying immune responses in Kawasaki Disease, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Lurie Children's Hospital of Chicago
Chicago, United States Active
Researchers
- Principal investigator: Rowley, Anne H — Lurie Children's Hospital of Chicago
- Study coordinator: Rowley, Anne H
Related research
Other NIH-funded projects on the same topics.
-
Gut bacteria and permeability linked to Kawasaki disease in kids
A pediatric-focused study exploring how the gut microbiome and intestinal barrier may influence Kawasaki disease and its inflammation.
-
Cell-free RNA test to quickly diagnose Kawasaki disease in children
A new blood test using cell-free RNA will help doctors diagnose Kawasaki disease in kids faster, leading to earlier treatment.
-
Role of sex in immune-stromal cell interactions driving Kawasaki disease vasculitis
This project looks at why Kawasaki disease causes heart problems in kids and how sex differences affect the immune cell interactions that lead to artery inflammation.
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Cell-free RNA signature to diagnose Kawasaki disease and guide personalized treatment in kids
A new blood test using tiny fragments of RNA found in the blood is being studied to help diagnose Kawasaki disease in children and tailor treatments to prevent heart complications.
-
Sex differences in immune–vessel cell interactions in Kawasaki disease
This project looks at how being male or female changes immune and blood-vessel cell behavior that leads to coronary artery damage in people with Kawasaki disease.
-
Gut bacteria and 'leaky' gut in Kawasaki disease
This research looks at whether changes in gut bacteria and a 'leaky' gut make Kawasaki disease worse in young children.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.