Finding specific targets related to Kawasaki Disease
Identifying Specific Antigenic Targets of Kawasaki Disease
['FUNDING_R01'] · LURIE CHILDREN'S HOSPITAL OF CHICAGO · NIH-10894818
This study is looking at Kawasaki Disease in kids to find out what triggers the immune response, which could help doctors diagnose it earlier and prevent serious heart problems.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | LURIE CHILDREN'S HOSPITAL OF CHICAGO (nih funded) |
| Locations | 1 site (CHICAGO, UNITED STATES) |
| Trial ID | NIH-10894818 on ClinicalTrials.gov |
What this research studies
This research investigates Kawasaki Disease (KD), a serious condition that can lead to heart disease in children. The team is working to identify the specific antigens associated with KD by analyzing the immune response in affected children. They are using advanced techniques such as single cell RT-PCR and monoclonal antibody production to pinpoint these antigens, which could lead to better diagnostic tests and treatments. The goal is to improve early diagnosis and reduce the risk of severe complications like coronary artery aneurysms.
Who could benefit from this research
Good fit: Ideal candidates for this research are children under 11 years old who have been diagnosed with Kawasaki Disease.
Not a fit: Patients who are older than 11 years or do not have Kawasaki Disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic tests and therapies for Kawasaki Disease, ultimately reducing the risk of heart complications in children.
How similar studies have performed: Previous research has shown promise in identifying immune responses in Kawasaki Disease, suggesting that this approach could yield valuable insights.
Where this research is happening
CHICAGO, UNITED STATES
- LURIE CHILDREN'S HOSPITAL OF CHICAGO — CHICAGO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ROWLEY, ANNE H — LURIE CHILDREN'S HOSPITAL OF CHICAGO
- Study coordinator: ROWLEY, ANNE H
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.