Finding small molecules that target cancer-related protein complexes
Official title: Discovery of small molecules targeting Polycomb repressive complexes 1 and 2
Funded at University of Southern California · NIH-10945915 · Data updated 2026-11-12
This study is looking for new ways to help treat certain types of cancer by finding small molecules that can block specific proteins that control how genes work in our cells.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Southern California NIH-funded |
| Lab location | 1 site (Los Angeles, UNITED STATES) |
| Project start | August 1, 2024 |
| Project end | July 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $563,663 |
| NIH project number | 1R01CA293188-01 |
| Project ID | NIH-10945915 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with B-cell lymphomas or other cancers associated with mutations in chromatin modifiers.
✕Less likely to help
Patients with cancers not related to chromatin dysregulation or those who do not have B-cell lymphomas may not benefit from this research.
What this research studies
This research focuses on discovering small molecules that can inhibit Polycomb Repressive Complexes 1 and 2, which are proteins involved in regulating gene expression and maintaining cellular identity. By targeting these complexes, the research aims to develop new treatments for cancers, particularly those with mutations in chromatin modifiers. The approach involves understanding how these complexes function and identifying specific inhibitors that can disrupt their activity, potentially leading to improved cancer therapies.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for certain types of cancers, particularly B-cell lymphomas.
How similar studies have gone: Previous research has shown success with similar approaches targeting chromatin modifiers, indicating potential for meaningful advancements in cancer treatment.
Where this research is happening
-
University of Southern California
Los Angeles, United States Active
Researchers
- Principal investigator: Bell, Oliver — University of Southern California
- Study coordinator: Bell, Oliver
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.