Finding small cell lung cancer early using blood tests and advanced imaging
Autoantibodies to tumor-derived neoepitopes as biomarkers and immunoPET agents for the early detection of small cell lung cancer
This project aims to find special antibodies in the blood to detect small cell lung cancer at its earliest stages, especially in people who smoke.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Fred Hutchinson Cancer Center NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-11161176 on NIH RePORTER |
What this research studies
Small cell lung cancer is very dangerous when found late, but much more treatable when caught early. This project aims to develop a new way to find this cancer sooner by looking for specific antibodies in your blood. These antibodies are like natural signals your body makes in response to tiny cancer cells. We also hope to use these signals to create a special imaging scan that can pinpoint small tumors, helping doctors guide treatment and improve outcomes.
Who could benefit from this research
Good fit: Ideal candidates would be individuals at high risk for lung cancer, such as heavy smokers, who undergo annual low-dose CT screenings.
Not a fit: Patients already diagnosed with advanced small cell lung cancer may not directly benefit from this early detection method.
Why it matters
Potential benefit: If successful, this could lead to a highly effective way to detect small cell lung cancer much earlier, significantly improving survival rates for patients.
How similar studies have performed: While the specific combination of autoantibodies and immunoPET for SCLC early detection is novel, the concept of using biomarkers for early cancer detection and advanced imaging for tumor localization has shown promise in other cancer types.
Where this research is happening
Seattle, United States
- Fred Hutchinson Cancer Center — Seattle, United States (Active)
Researchers
- Principal investigator: Lampe, Paul D. — Fred Hutchinson Cancer Center
- Study coordinator: Lampe, Paul D.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.