Finding safe ways to manage pain in patients with cirrhosis
Official title: Using real-world evidence to define safe pain management strategies in cirrhosis
Funded at University of California, San Francisco · NIH-10928265 · Data updated 2026-11-12
This study is looking at how to help people with cirrhosis manage their pain better by checking how well different pain medications work and what side effects they might have, so that doctors can provide safer and more effective treatment options.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | September 15, 2023 |
| Project end | July 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $188,635 |
| NIH project number | 5K23DK135901-02 |
| Project ID | NIH-10928265 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with cirrhosis who experience pain.
✕Less likely to help
Patients without a diagnosis of cirrhosis or those who do not experience pain may not benefit from this research.
What this research studies
This research investigates how pain is managed in patients with cirrhosis, a condition where up to 80% of individuals experience pain. The study aims to gather real-world evidence on the use of pain medications and their potential side effects in this population. By analyzing data from over 500,000 Veterans with cirrhosis, the research will identify effective pain management strategies and develop guidelines to help healthcare providers treat pain safely and effectively.
Why it matters
Potential benefit: If successful, this research could lead to improved pain management strategies for patients with cirrhosis, enhancing their quality of life.
How similar studies have gone: Previous research has shown that real-world evidence can effectively inform pain management strategies, suggesting potential success for this approach.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Rubin, Jessica — University of California, San Francisco
- Study coordinator: Rubin, Jessica
Related research
Other NIH-funded projects on the same topics.
-
Cancer Pain Management for Asian American Breast Cancer Survivors with Depressive Symptoms
A technology-based program helps Asian American breast cancer survivors with depressive symptoms manage chronic pain more effectively from home using a web app and mobile tools.
-
Statin therapy for people with compensated cirrhosis
A big, long-term study at a major university is looking at whether statins can help people with compensated cirrhosis live longer and feel better.
-
Liver Cirrhosis Network: Centers for Clinical Research
A multicenter study in people with cirrhosis from different causes (including HIV, NASH, and alcohol-related liver disease) to collect data and samples and test new ways to predict and monitor disease progression.
-
Outcomes in cirrhosis from different causes and the role of HIV and simvastatin
This study looks at how cirrhosis from alcohol, HIV, and other causes affects patients and whether simvastatin can influence outcomes.
-
Liver Cirrhosis Network: Mayo Clinic's Clinical Research Center
A Mayo Clinic-led project will follow and help people with compensated cirrhosis, using data, imaging, and a big AI tool to predict when complications may happen and test whether a statin can improve outcomes.
-
Understanding how risk factors affect progression of cirrhosis and response to statins in patients with cirrhosis
This project follows people with cirrhosis to see what factors speed up their liver disease and whether statin medicines help prevent worsening.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.