Finding protein markers that indicate risk for abdominal aortic aneurysm
Official title: Identifying Proteomics Risk Markers for Abdominal Aortic Aneurysm
Funded at University of Minnesota · NIH-10846849 · Data updated 2026-11-12
This study is looking for certain proteins in the blood that might help predict if someone is at risk of developing an abdominal aortic aneurysm (AAA), which is a serious health issue, and it's designed for anyone interested in understanding more about their health risks.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project start | July 15, 2021 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $487,254 |
| NIH project number | 5R01HL155209-04 |
| Project ID | NIH-10846849 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults, particularly those with risk factors for abdominal aortic aneurysm, such as a family history of the condition or other cardiovascular issues.
✕Less likely to help
Patients who are younger and do not have any risk factors for abdominal aortic aneurysm may not benefit from this research.
What this research studies
This research aims to identify specific protein markers in the blood that can indicate a person's risk of developing abdominal aortic aneurysm (AAA), a serious condition that can lead to life-threatening complications. By analyzing a large dataset of blood samples from participants over many years, the study will look for patterns and markers that correlate with the development of AAA. The research will utilize advanced proteomic techniques to assess thousands of proteins and will also replicate findings in other population studies to ensure accuracy and reliability.
Why it matters
Potential benefit: If successful, this research could lead to better screening methods and risk assessment for abdominal aortic aneurysm, potentially saving lives through earlier intervention.
How similar studies have gone: Previous research has successfully identified epidemiological risk factors for AAA, suggesting that this proteomic approach may also yield significant findings.
Where this research is happening
-
University of Minnesota
Minneapolis, United States Active
Researchers
- Principal investigator: Tang, Weihong — University of Minnesota
- Study coordinator: Tang, Weihong
Related research
Other NIH-funded projects on the same topics.
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How the small regulator miR-146a affects abdominal aortic aneurysm
This project aims to see if boosting a natural genetic regulator called miR-146a can help slow or prevent growth and rupture of abdominal aortic aneurysms in people with this condition.
-
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Scientists are studying how a molecule called MOF and inflammatory signals affect abdominal aortic aneurysms to find ways to slow or stop their enlargement.
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Endovascular Suturing Device to Improve Endograft Fixation in Abdominal Aortic Aneurysm
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Triglyceride-rich lipoproteins and abdominal aortic aneurysm growth
A study exploring how fats in the blood (TRLs) influence the growth of abdominal aortic aneurysms to find non-surgical ways to protect against rupture, especially in people aged 65 and older.
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Using genetics to uncover how abdominal aortic aneurysms develop
A research team will study how genetic differences influence abdominal aortic aneurysm to help with earlier prevention and better treatment.
-
Phospholipid-based nanotherapies to treat abdominal aortic aneurysm
A new nanoparticle treatment is being developed to slow or stop the growth of abdominal aortic aneurysms in adults.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.