Finding personalized types of type 2 diabetes using genetic and molecular data
GEneration and assessment of Multi-omic informed Subtypes of Type 2 Diabetes in Diverse Populations (GEMS-T2D)
['FUNDING_U01'] · MASSACHUSETTS GENERAL HOSPITAL · NIH-11172665
This project uses people’s genetics, blood tests, and health records to find distinct kinds of type 2 diabetes that apply to diverse groups.
Quick facts
| Phase | ['FUNDING_U01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MASSACHUSETTS GENERAL HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-11172665 on ClinicalTrials.gov |
What this research studies
You would be part of a large effort that combines genetic data, blood-based molecular tests, and clinical information from thousands of people with type 2 diabetes. Researchers will group people into more precise subtypes using these multiple data types and then connect those groups to symptoms, complications, and treatment responses. The team aims to create a standardized classification that works across different populations and in routine care. If successful, this could help doctors tailor care more precisely for different types of diabetes.
Who could benefit from this research
Good fit: Adults with type 2 diabetes from diverse racial and ethnic backgrounds who can share blood samples, genetic information, and medical records are the ideal participants.
Not a fit: People without type 2 diabetes (for example those with type 1 diabetes or unrelated conditions) are unlikely to receive direct benefit from this work.
Why it matters
Potential benefit: Could help match people with type 2 diabetes to more targeted treatments and better predict complications.
How similar studies have performed: Earlier studies have found clinical or genetic subgroups of type 2 diabetes, but integrating broad multi-omic data across diverse cohorts is a newer approach with promise that still needs large-scale validation.
Where this research is happening
BOSTON, UNITED STATES
- MASSACHUSETTS GENERAL HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: UDLER, MIRIAM SARGON — MASSACHUSETTS GENERAL HOSPITAL
- Study coordinator: UDLER, MIRIAM SARGON
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Adult-Onset Diabetes Mellitus