Finding non-surgical ways to manage abdominal aortic aneurysms
Mechanistic and Translational Determination of PERK-targeting Strategies for Non-surgical Management of Abdominal Aortic Aneurysm
This study is looking at a new way to treat abdominal aortic aneurysms without surgery by focusing on a protein called PERK, which could help slow down or even reverse the condition, making it safer for patients like you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Virginia NIH-funded |
| Lab location | 1 site (Charlottesville, United States) |
| Project ID | NIH-11072064 on NIH RePORTER |
What this research studies
This research focuses on developing non-invasive treatments for abdominal aortic aneurysms (AAA), a serious condition that often requires risky surgical intervention. The study investigates the role of a specific protein, PERK, which is involved in the degeneration of smooth muscle cells in the aorta. By targeting PERK, the researchers aim to slow down or reverse the progression of AAA, potentially leading to new drug therapies. The approach includes both pharmacological methods and innovative delivery systems to effectively address this condition.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults who are at risk of developing or have been diagnosed with abdominal aortic aneurysms.
Not a fit: Patients who are not at risk for abdominal aortic aneurysms or those who have already undergone surgical treatment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide a groundbreaking non-surgical treatment option for patients with abdominal aortic aneurysms.
How similar studies have performed: While the approach of targeting PERK in the context of AAA is innovative, preliminary data suggests that similar strategies have shown promise in related vascular conditions.
Where this research is happening
Charlottesville, United States
- University of Virginia — Charlottesville, United States (Active)
Researchers
- Principal investigator: Kent, K Craig — University of Virginia
- Study coordinator: Kent, K Craig
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.