Finding new ways to understand and treat tumors caused by NF1 gene loss in Schwann cells
Identification of Novel Pathways Causing NF1-Driven Schwann Cell Tumors
This study is looking into how tumors develop in certain cells when a specific gene is missing, and it's aimed at finding new treatments for people affected by this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project ID | NIH-10991410 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind tumors formed in Schwann cells due to the loss of the NF1 gene, which is crucial for regulating cell growth. The team will identify the proteins that interact with neurofibromin, the product of the NF1 gene, and how these interactions contribute to tumor development. Using advanced techniques in genetics and molecular biology, they will study these processes both in laboratory settings and in animal models. The ultimate goal is to explore targeted therapies that could effectively treat these tumors.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with neurofibromatosis type 1 (NF1) who are experiencing Schwann cell tumors.
Not a fit: Patients without a diagnosis of NF1 or those who do not have Schwann cell tumors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for patients with NF1-related Schwann cell tumors, improving their health outcomes.
How similar studies have performed: Previous research has shown promise in understanding RAS proteins and their role in tumorigenesis, suggesting that this approach could yield valuable insights.
Where this research is happening
Cincinnati, United States
- Cincinnati Childrens Hosp Med Ctr — Cincinnati, United States (Active)
Researchers
- Principal investigator: Ratner, Nancy — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Ratner, Nancy
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.