Finding new ways to treat pancreatic cancer by reprogramming cancer cells
Project 1: Overcoming therapeutic resistance in pancreatic cancer through epigenetic reprogramming
This work looks for new ways to make pancreatic cancer treatments more effective by changing how cancer cells behave.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Salk Institute for Biological Studies NIH-funded |
| Lab location | 1 site (La Jolla, UNITED STATES) |
| Project ID | NIH-11167605 on NIH RePORTER |
What this research studies
Pancreatic cancer is a very serious disease that often resists current treatments like chemotherapy and immunotherapy. This project explores how to make these treatments work better by targeting the cancer cells' 'epigenetic programs,' which are like switches that control how genes are turned on or off. We are testing specific drugs that can flip these switches, making cancer cells more vulnerable to existing therapies. The goal is to find combinations of treatments that can overcome the cancer's ability to resist drugs.
Who could benefit from this research
Good fit: This foundational work is for patients with pancreatic cancer who currently face challenges with treatment resistance.
Not a fit: Patients without pancreatic cancer would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to more effective treatments for pancreatic cancer, improving patient outcomes and survival.
How similar studies have performed: While the specific approach of combining epigenetic reprogramming with other therapies for pancreatic cancer is being explored, some related strategies have shown promise in other cancer types.
Where this research is happening
La Jolla, UNITED STATES
- Salk Institute for Biological Studies — La Jolla, United States (Active)
Researchers
- Principal investigator: Evans, Ronald M — Salk Institute for Biological Studies
- Study coordinator: Evans, Ronald M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.