Finding new ways to treat glioblastoma by targeting its metabolism
Official title: Developing therapeutic strategies to elicit metabolic synthetic lethality in glioblastoma
Funded at William Beaumont Hospital Research Inst · NIH-10756087 · Data updated 2026-11-12
This study is looking at how glioblastoma, a tough type of brain cancer, uses fat for energy to survive and grow, with the hope of finding new ways to treat patients by targeting these unique processes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | William Beaumont Hospital Research Inst NIH-funded |
| Lab location | 1 site (Royal Oak, United States) |
| Project start | December 1, 2019 |
| Project end | November 30, 2025 |
| Funding year | 2024 |
| Award (this year) | $323,500 |
| NIH project number | 5R01NS110838-05 |
| Project ID | NIH-10756087 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with glioblastoma, particularly those with the mesenchymal subtype of the tumor.
✕Less likely to help
Patients with other types of brain tumors or those who do not have glioblastoma may not benefit from this research.
What this research studies
This research investigates glioblastoma, a highly aggressive brain cancer, by focusing on its unique metabolic processes. The team studies how glioblastoma cells adapt their metabolism to survive and grow in different environments, particularly by using fatty acids as an energy source. By analyzing patient-derived tumor samples and using preclinical models, they aim to identify potential therapeutic strategies that could disrupt these metabolic pathways, ultimately leading to more effective treatments for patients.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options that specifically target the metabolism of glioblastoma cells, potentially improving survival rates for patients.
How similar studies have gone: Previous research has shown promise in targeting metabolic pathways in cancer treatment, suggesting that this approach could be effective for glioblastoma as well.
Where this research is happening
-
William Beaumont Hospital Research Inst
Royal Oak, United States Active
Researchers
- Principal investigator: Chinnaiyan, Prakash — William Beaumont Hospital Research Inst
- Study coordinator: Chinnaiyan, Prakash
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.