Finding new ways to treat glioblastoma by targeting its metabolism
Developing therapeutic strategies to elicit metabolic synthetic lethality in glioblastoma
This study is looking at how glioblastoma, a tough type of brain cancer, uses fat for energy to survive and grow, with the hope of finding new ways to treat patients by targeting these unique processes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | William Beaumont Hospital Research Inst NIH-funded |
| Lab location | 1 site (Royal Oak, United States) |
| Project ID | NIH-10756087 on NIH RePORTER |
What this research studies
This research investigates glioblastoma, a highly aggressive brain cancer, by focusing on its unique metabolic processes. The team studies how glioblastoma cells adapt their metabolism to survive and grow in different environments, particularly by using fatty acids as an energy source. By analyzing patient-derived tumor samples and using preclinical models, they aim to identify potential therapeutic strategies that could disrupt these metabolic pathways, ultimately leading to more effective treatments for patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with glioblastoma, particularly those with the mesenchymal subtype of the tumor.
Not a fit: Patients with other types of brain tumors or those who do not have glioblastoma may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options that specifically target the metabolism of glioblastoma cells, potentially improving survival rates for patients.
How similar studies have performed: Previous research has shown promise in targeting metabolic pathways in cancer treatment, suggesting that this approach could be effective for glioblastoma as well.
Where this research is happening
Royal Oak, United States
- William Beaumont Hospital Research Inst — Royal Oak, United States (Active)
Researchers
- Principal investigator: Chinnaiyan, Prakash — William Beaumont Hospital Research Inst
- Study coordinator: Chinnaiyan, Prakash
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.