Finding new ways to treat difficult cases of T-cell leukemia
Official title: Targeting the Microenvironment/Oncogene Cooperation to treat poor prognosis T-ALL
Funded at Beckman Research Institute/city of Hope · NIH-11036357 · Data updated 2026-11-12
This study is looking at how the environment around cancer cells affects children with relapsed or hard-to-treat Acute T-Cell Lymphoblastic Leukemia, with the goal of finding better treatment options for those who haven't had success with current therapies.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beckman Research Institute/city of Hope NIH-funded |
| Lab location | 1 site (Duarte, United States) |
| Project start | March 9, 2023 |
| Project end | February 29, 2028 |
| Funding year | 2025 |
| Award (this year) | $519,672 |
| NIH project number | 5R01CA269740-03 |
| Project ID | NIH-11036357 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children and young adults diagnosed with relapsed or refractory Acute T-Cell Lymphoblastic Leukemia.
✕Less likely to help
Patients with other types of leukemia or those who have not experienced relapse may not benefit from this research.
What this research studies
This research focuses on improving treatment options for patients with relapsed or refractory Acute T-Cell Lymphoblastic Leukemia (T-ALL), a type of cancer that primarily affects children and has poor survival rates. The team aims to understand how cancer cells interact with their surrounding environment, particularly how signals from the microenvironment can influence the behavior of T-ALL cells. By studying these interactions, the researchers hope to identify new therapeutic targets that could lead to more effective treatments for patients who do not respond to current therapies.
Why it matters
Potential benefit: If successful, this research could lead to new treatment strategies that significantly improve survival rates for patients with difficult-to-treat T-ALL.
How similar studies have gone: Previous research has shown promise in targeting microenvironmental factors in leukemia, suggesting that this approach could yield beneficial results.
Where this research is happening
-
Beckman Research Institute/city of Hope
Duarte, United States Active
Researchers
- Principal investigator: Carlesso, Nadia — Beckman Research Institute/city of Hope
- Study coordinator: Carlesso, Nadia
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.