Finding new ways to treat chemotherapy-resistant ovarian cancer.

Who could benefit from this research

What this research studies

This research focuses on understanding and overcoming the challenges of chemotherapy resistance in high-grade serous ovarian carcinoma (HGSOC), the most common and deadly form of ovarian cancer. The project aims to identify novel targets and biomarkers that can help in treating patients whose tumors have become resistant to standard platinum-based chemotherapy. By studying the mechanisms that lead to this resistance, researchers hope to develop new therapeutic strategies that can improve patient outcomes. The approach involves interdisciplinary collaboration and advanced techniques to gain insights into the cancer cells' behavior and their environment.

Why it matters

Where this research is happening

• VA Greater Los Angeles Healthcare System
  Los Angeles, United States Active

Researchers

• Principal investigator: Memarzadeh, Sanaz — VA Greater Los Angeles Healthcare System
• Study coordinator: Memarzadeh, Sanaz

Related research

Other NIH-funded projects on the same topics.

• Understanding the experience of ovarian cancer after diagnosis to improve survivorship

  This NIH grant funds a mixed-methods study to better understand physical and emotional challenges faced by ovarian cancer survivors and how supportive care can help them live better after diagnosis.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11624191

• Targeting quiescent ovarian cancer cells to overcome chemotherapy resistance

  A study focusing on why some ovarian cancer cells pause dividing and resist chemotherapy, with the goal of finding new treatment targets for relapsed disease.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11608576

• Photodynamic lipids to boost chemotherapy for metastatic ovarian cancer

  A patient-friendly approach tests a light-activated method to make ovarian cancer metastases more sensitive to chemotherapy.

  NIH research Utah State Higher Education System--University of Utah · Salt Lake City, United States · NIH-11601571

• Integrated framework to validate and quantify proteoforms in patient-derived ovarian cancer cells

  A collaboration will combine advanced top-down proteomics with a new computational method to precisely identify and measure intact proteoforms in tiny samples from ovarian cancer cells.

  NIH research University of Alabama in Tuscaloosa · Tuscaloosa, United States · NIH-11566393

• Overcoming platinum resistance in ovarian cancer: finding biomarkers and new targets

  Researchers are looking for new biomarkers and targets to help prevent or overcome platinum resistance in high‑risk ovarian cancer so patients have better chances at long-term control.

  NIH research VA Greater Los Angeles Healthcare System · Los Angeles, United States · NIH-11498011

• Alternative NF-kB activation after chemotherapy in ovarian cancer

  This grant studies how ovarian cancer might come back after chemotherapy by looking at specific signaling pathways in cancer cells and the tumor environment.

  NIH research San Diego State University · San Diego, United States · NIH-11473227

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.