Finding new ways to target antibodies against human coronaviruses
Novel B cell epitope discovery against human coronaviruses
This study is looking for new ways to help your immune system make strong antibodies against human coronaviruses, like the one that causes COVID-19, by exploring parts of the virus that can trigger a response, which could improve vaccines and treatments for everyone.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Scripps Research Institute, the NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-11109040 on NIH RePORTER |
What this research studies
This research focuses on discovering novel B cell epitopes that can trigger the immune system to produce effective antibodies against human coronaviruses, including SARS-CoV-2. By analyzing the spike protein of the virus and identifying both known and previously unexplored epitopes, the research aims to enhance the effectiveness of vaccines and treatments. The approach involves using advanced techniques to isolate B cells from diverse donor samples and characterize their responses to these epitopes. This could lead to the development of broadly neutralizing antibodies that are effective against various strains of coronaviruses.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals who have been infected with or vaccinated against SARS-CoV-2 and are willing to contribute blood samples for antibody analysis.
Not a fit: Patients who are not affected by coronaviruses or those who have not been vaccinated or infected may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective vaccines and therapies for COVID-19 and other coronavirus-related diseases.
How similar studies have performed: Previous research has successfully identified B cell epitopes for other viruses, indicating that this approach has potential for success in the context of coronaviruses.
Where this research is happening
La Jolla, United States
- Scripps Research Institute, the — La Jolla, United States (Active)
Researchers
- Principal investigator: Wilson, Ian a — Scripps Research Institute, the
- Study coordinator: Wilson, Ian a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.