Finding new ways to target and treat antibiotic-resistant bacterial infections
Discovery and characterization of new bacterial cell wall targets and inhibitors to treat resistant infections
['FUNDING_R01'] · HARVARD MEDICAL SCHOOL · NIH-11049711
This study is looking at how certain antibiotics work on the walls of bacteria to help create new treatments for infections that don’t respond to current medicines, so patients can have better options for fighting stubborn infections.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | HARVARD MEDICAL SCHOOL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-11049711 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the structure and function of bacterial cell walls, which are essential for bacterial growth and survival. By investigating how certain antibiotics interact with these cell walls, the researchers aim to develop new treatments for infections that are resistant to current antibiotics. The study will explore different mechanisms of action of glycopeptide antibiotics and how they can be optimized to enhance their effectiveness. Patients may benefit from new antibiotic therapies that are specifically designed to overcome resistance.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from infections caused by antibiotic-resistant bacteria.
Not a fit: Patients with infections that are not caused by bacterial pathogens or those who are not resistant to current antibiotics may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of new antibiotics that effectively treat infections resistant to existing treatments.
How similar studies have performed: Previous research has shown promise in targeting bacterial cell walls to develop new antibiotics, indicating that this approach has potential for success.
Where this research is happening
BOSTON, UNITED STATES
- HARVARD MEDICAL SCHOOL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WALKER, SUZANNE — HARVARD MEDICAL SCHOOL
- Study coordinator: WALKER, SUZANNE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: antibiotic resistant infections