Finding new ways to stop bacteria from resisting antibiotics
Discovery of efflux pump inhibitors using a high-throughout bacterial assay
This study is looking for new ways to help antibiotics work better against stubborn bacteria that have become resistant, by finding special blockers that stop bacteria from pushing the medicine out of their system, making it easier for people to get the treatment they need.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11038326 on NIH RePORTER |
What this research studies
This research focuses on developing new therapies to combat antibiotic resistance, a major global health threat. It aims to discover efflux pump inhibitors (EPIs) that can block the mechanisms bacteria use to expel antibiotics, making treatments more effective. The researchers will use a high-throughput screening method to identify these inhibitors without the need for extensive sample preparation, which can be time-consuming. By co-expressing efflux pumps with a library of antibodies in E. coli, they hope to find effective blockers that can enhance the efficacy of existing antibiotics.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients suffering from infections caused by antibiotic-resistant bacteria.
Not a fit: Patients with infections that are not caused by antibiotic-resistant bacteria may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve the effectiveness of antibiotics against resistant bacterial infections.
How similar studies have performed: Previous research has shown promise in developing efflux pump inhibitors, indicating that this approach has potential for success.
Where this research is happening
New York, United States
- New York University — New York, United States (Active)
Researchers
- Principal investigator: Traaseth, Nathaniel J. — New York University
- Study coordinator: Traaseth, Nathaniel J.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.