Finding new ways to reverse fentanyl overdoses
Negative allosteric modulation of mu opioid receptors to reverse fentanyl overdose
['FUNDING_R21'] · TRUSTEES OF INDIANA UNIVERSITY · NIH-10952479
This study is looking at a new way to make naloxone, the medicine used to treat fentanyl overdoses, work better and faster by combining it with other compounds, which could help save lives in emergency situations.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | TRUSTEES OF INDIANA UNIVERSITY (nih funded) |
| Locations | 1 site (BLOOMINGTON, UNITED STATES) |
| Trial ID | NIH-10952479 on ClinicalTrials.gov |
What this research studies
This research investigates a novel approach to enhance the effectiveness of existing treatments for fentanyl overdose, specifically by using negative allosteric modulators of mu opioid receptors. The study aims to improve the action of naloxone, the current standard treatment, by combining it with compounds that can help it work more effectively against fentanyl's potent effects. By exploring the use of cannabidiol analogs, the research seeks to develop a faster-acting therapy that could potentially save lives during opioid overdose emergencies. Patients may benefit from this research if it leads to improved treatment options for opioid overdoses.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals at risk of opioid overdose, particularly those using fentanyl or similar potent opioids.
Not a fit: Patients who do not use opioids or are not at risk of opioid overdose may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for reversing fentanyl overdoses, potentially saving many lives.
How similar studies have performed: While the use of negative allosteric modulators is a relatively novel approach, preliminary studies have shown promise in enhancing the effects of existing opioid overdose treatments.
Where this research is happening
BLOOMINGTON, UNITED STATES
- TRUSTEES OF INDIANA UNIVERSITY — BLOOMINGTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MACKIE, KENNETH — TRUSTEES OF INDIANA UNIVERSITY
- Study coordinator: MACKIE, KENNETH
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.