Finding new ways to reduce heart disease in people with type 1 diabetes
Novel Targets for Reducing Atherosclerosis in Type 1 Diabetes
This study is looking at how insulin can help keep cholesterol and inflammation in check in the liver for people with type 1 diabetes, with the goal of finding new treatments to lower their risk of heart disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10991829 on NIH RePORTER |
What this research studies
This research investigates how insulin affects cholesterol and inflammation in the liver, particularly in individuals with type 1 diabetes who are at a higher risk for heart disease. The team aims to develop new drugs that can mimic the protective effects of insulin on the liver to help maintain healthy lipid levels and reduce inflammation. By studying a specific target in the liver, they hope to understand how restoring this target can prevent the progression of atherosclerosis, a condition that leads to cardiovascular disease. The research involves both laboratory studies and animal models to test their hypotheses.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with type 1 diabetes who are at risk for cardiovascular disease.
Not a fit: Patients without type 1 diabetes or those who do not have cardiovascular disease risk factors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly lower the risk of heart disease in patients with type 1 diabetes.
How similar studies have performed: Previous research has shown promising results in targeting metabolic pathways to reduce cardiovascular risks, suggesting that this approach may be effective.
Where this research is happening
Boston, United States
- Boston Children's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Biddinger, Sudha B — Boston Children's Hospital
- Study coordinator: Biddinger, Sudha B
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.