Finding new ways to predict outcomes in alcoholic hepatitis
Biomarkers of Alcoholic Hepatitis
['FUNDING_R01'] · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · NIH-10851714
This study is looking for new ways to predict how well people with alcoholic hepatitis will respond to treatment by examining tiny proteins in their blood, which could help doctors provide better care for patients with this serious liver condition.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF PITTSBURGH AT PITTSBURGH (nih funded) |
| Locations | 1 site (PITTSBURGH, UNITED STATES) |
| Trial ID | NIH-10851714 on ClinicalTrials.gov |
What this research studies
This research aims to develop minimally invasive methods to predict outcomes in patients with alcoholic hepatitis (AH), a serious liver condition. The team will analyze changes in low molecular weight peptides found in blood, known as the peptidome, to identify new biomarkers that could indicate how well a patient might respond to treatment. By understanding the dynamics of the liver's extracellular matrix during injury, the researchers hope to create probabilistic models that can better forecast patient outcomes. This approach could lead to more effective management strategies for those suffering from AH.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with alcoholic hepatitis who are seeking new treatment options.
Not a fit: Patients with non-alcoholic liver diseases or those not diagnosed with alcoholic hepatitis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could significantly improve the ability to predict patient outcomes in alcoholic hepatitis, leading to better-targeted treatments.
How similar studies have performed: Previous research has shown promise in using biomarkers for liver diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
PITTSBURGH, UNITED STATES
- UNIVERSITY OF PITTSBURGH AT PITTSBURGH — PITTSBURGH, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ARTEEL, GAVIN E — UNIVERSITY OF PITTSBURGH AT PITTSBURGH
- Study coordinator: ARTEEL, GAVIN E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.