Finding new ways to lower heart disease risk
New Approaches to Reduce Residual Cardiovascular Risk
This study is looking at ways to lower heart disease risks for people who have low LDL cholesterol but still face other issues, by exploring how certain proteins affect triglyceride levels and testing new treatments that could help keep your heart healthier.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project ID | NIH-11004389 on NIH RePORTER |
What this research studies
This research focuses on understanding and reducing the remaining cardiovascular risks that persist even in patients with low LDL cholesterol levels. It investigates the role of specific proteins and lipoproteins in heart disease, particularly those that contribute to elevated triglyceride levels. The research involves innovative screening methods to identify compounds that can block the production of harmful lipoproteins, potentially leading to new treatments. Patients may benefit from insights into how their cardiovascular risk can be managed more effectively.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with high cardiovascular risk despite low LDL cholesterol levels.
Not a fit: Patients who have normal cholesterol levels and do not have a history of cardiovascular disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that significantly lower the risk of heart disease for patients who currently have limited treatment options.
How similar studies have performed: Previous research has shown promise in targeting similar pathways to reduce cardiovascular risk, indicating that this approach may yield beneficial results.
Where this research is happening
Dallas, United States
- Ut Southwestern Medical Center — Dallas, United States (Active)
Researchers
- Principal investigator: Horton, Jay D. — Ut Southwestern Medical Center
- Study coordinator: Horton, Jay D.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.